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Neuroprotective actions of 2,4-dinitrophenol: Friend or foe?

Abstract 2,4-dinitrophenol (DNP) has long been known to be toxic at high concentrations, an effect related to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we reported that low concentrations of DNP protect neurons against the toxicity of the amyloid-b peptide. Sinc...

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Principais autores: Sérgio Teixeira Ferreira, Fernanda Guarino De Felice
Format: Artigo
Sprog:Inglês
Udgivet: Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
Serier:Dementia & Neuropsychologia
Fag:
2,4-dinitrophenol
amyloid-b peptide
neurodegenerative diseases
neuroprotection
oxidative stress
therapy
Online adgang:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642007000400334&lng=en&tlng=en
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