Reversible covalent c-Jun N-terminal kinase inhibitors targeting a specific cysteine by precision-guided Michael-acceptor warheads

Abstract There has been a surge of interest in covalent inhibitors for protein kinases in recent years. Despite success in oncology, the off-target reactivity of these molecules is still hampering the use of covalent warhead-based strategies. Herein, we disclose the development of precision-guided w...

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Главные авторы:	Dániel Bálint, Ádám Levente Póti, Anita Alexa, Péter Sok, Krisztián Albert, Lili Torda, Dóra Földesi-Nagy, Dániel Csókás, Gábor Turczel, Tímea Imre, Eszter Szarka, Ferenc Fekete, Isabel Bento, Márton Bojtár, Roberta Palkó, Pál Szabó, Katalin Monostory, Imre Pápai, Tibor Soós, Attila Reményi
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2024-10-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-024-52573-2
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