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Regulation of STING activity in DNA sensing by ISG15 modification

Summary: Sensing of human immunodeficiency virus type 1 (HIV-1) DNA is mediated by the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling axis. Signal transduction and regulation of this cascade is achieved by post-translational modifications. Here we show that cGAS-STING-...

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Autori principali: Chaohui Lin, Edmund Osei Kuffour, Nina V. Fuchs, Christoph G.W. Gertzen, Jesko Kaiser, Maximilian Hirschenberger, Xiao Tang, Haifeng C. Xu, Oliver Michel, Ronny Tao, Alexandra Haase, Ulrich Martin, Thomas Kurz, Ingo Drexler, Boris Görg, Philipp A. Lang, Tom Luedde, Konstantin M.J. Sparrer, Holger Gohlke, Renate König, Carsten Münk
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2023-11-01
Serie:Cell Reports
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CP: Molecular biology
Accesso online:http://www.sciencedirect.com/science/article/pii/S2211124723012895
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