Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex
Insulin signaling controls metabolic homeostasis. Here, we report the cryo-EM structure of full-length insulin receptor (IR) and insulin complex in the active state. This structure unexpectedly reveals that maximally four insulins can bind the ‘T’-shaped IR dimer at four distinct sites related by 2-...
Salvato in:
| Autori principali: | , , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications Ltd
2019-08-01
|
| Serie: | eLife |
| Soggetti: | |
| Accesso online: | https://elifesciences.org/articles/48630 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|