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Case Report: A novel intergenic MIR4299/MIR8070-RET fusion with RET amplification and clinical response to pralsetinib in a lung adenocarcinoma patient

The identification of receptor-tyrosine kinase gene (RET) fusions in lung cancer has become crucial owing to actionable events that predict responsiveness to tyrosine kinase inhibitors (TKIs). However, RET fusions with distinct partner genes respond differently to TKIs. In this case, a 60-year-old m...

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Principais autores: Sha-Sha Wang, Fang Wang, Zhen Zeng, Fang Gao, Huan-Huan Liu, Hui-Na Wang, Yi Hu, Hai-Feng Qin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-09-01
Serier:Frontiers in Oncology
Fag:
RET intergenic fusion
pralsetinib
lung adenocarcinoma
novel intergenic
tyrosine kinase inhibitors
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2022.929763/full
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