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Deciphering a missing piece of the branched-chain amino acids uptake puzzle: YhjE is an L-isoleucine and L-valine transporter in Escherichia coli K-12

Branched-chain amino acid (BCAA) uptake in bacteria underpins fitness, pathogenesis, and industrial strain performance, yet the transport landscape, even in Escherichia coli, remains incomplete. Here, we identify and characterize YhjE as a BCAA permease specific for L-isoleucine and L-valine. Select...

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Principais autores: Sergey V. Molev, Agnessa A. Stepanova, Tatiana V. Vybornaya, Andrey A. Khozov, Makar M. Surkov, Gennadii A. Badun, Maria G. Chernysheva, Alexander I. Netrusov, Alexander S. Yanenko, Sergey P. Sineoky, Dmitrii M. Bubnov
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-12-01
Serier:Frontiers in Microbiology
Fag:
Escherichia coli
L-isoleucine uptake
L-valine uptake
transmembrane transport
amino acid transporter
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1727951/full
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