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ISO-upregulated BECN1 specifically promotes LC3B-dependent autophagy and anticancer activity in invasive bladder cancer

Isorhapontigenin (ISO), an active compound isolated from the Chinese herb Gnetum Cleistostachyum, exhibited strong preventive and therapeutic effects on bladder cancer (BC) both in vitro and in vivo. Our previous studies revealed that ISO-induced autophagy is crucial for its anti-cancer activity. Ho...

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Principais autores: Xiaohui Hua, Daimin Xiang, Jiheng Xu, Shouyue Zhang, Shuai Wu, Zhongxian Tian, Junlan Zhu, Chuanshu Huang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-01-01
Serier:Translational Oncology
Fag:
Isorhapontigenin (ISO)
LC3B
autophagy
BECN1
NCL
Online adgang:http://www.sciencedirect.com/science/article/pii/S1936523324003048
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