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The effects of 17α-estradiol treatment on endocrine system revealed by single-nucleus transcriptomic sequencing of hypothalamus

This study investigated 17α-estradiol’s effects on aged hypothalamic physiological activity via long-term administration. Single-nucleus transcriptomic sequencing (snRNA-seq) was performed on pooled hypothalami from each group: aged male Norway brown rats treated with 17α-estradiol (O.T), aged contr...

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Principais autores: Lei Li, Guanghao Wu, Xiaolei Xu, Junling Yang, Lirong Yi, Ziqing Yang, Zheng Mo, Li Xing, Ying Shan, Zhuo Yu, Yinchuan Li
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2025-09-01
coleção:eLife
Assuntos:
hypothalamus
17α-estradiol
snRNA-seq
Gnrh
Crh
Oxt
Acesso em linha:https://elifesciences.org/articles/100346
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