Structure-Function Relationships of the Neisserial EptA Enzyme Responsible for Phosphoethanolamine Decoration of Lipid A: Rationale for Drug Targeting

Bacteria cause disease by two general mechanisms: the action of their toxins on host cells and induction of a pro-inflammatory response that can lead to a deleterious cytokine/chemokine response (e.g., the so-called cytokine storm) often seen in bacteremia/septicemia. These major mechanisms may over...

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Autors principals:	Charlene M. Kahler, K. L. Nawrocki, A. Anandan, Alice Vrielink, William M. Shafer
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2018-08-01
Col·lecció:	Frontiers in Microbiology
Matèries:	anti-virulence phosphoethanolamine transferase lipopolysaccharide multidrug resistance N. meningitidis N. gonorrhoeae
Accés en línia:	https://www.frontiersin.org/article/10.3389/fmicb.2018.01922/full
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