Exogenous and Endogenous Phosphoethanolamine Transferases Differently Affect Colistin Resistance and Fitness in Pseudomonas aeruginosa

Colistin represents a last-line treatment option for infections caused by multidrug resistant Gram-negative pathogens, including Pseudomonas aeruginosa. Colistin resistance generally involves the modification of the lipid A moiety of lipopolysaccharide (LPS) with positively charged molecules, namely...

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Hauptverfasser:	Matteo Cervoni, Alessandra Lo Sciuto, Chiara Bianchini, Carmine Mancone, Francesco Imperi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-10-01
Schriftenreihe:	Frontiers in Microbiology
Schlagworte:	cell envelope EptA lipid A MCR phosphoethanolamine (PEtN) polymyxin
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.778968/full
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