Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis

Abstract Background Sepsis-associated encephalopathy (SAE) is a severe neurological condition caused by sepsis, and presents with symptoms ranging from delirium and coma to long-term cognitive dysfunction. SAE is acknowledged as a widespread brain impairment characterized by the activation of microg...

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Huvudupphov:	Lijiao Chen, Shiyuan Luo, Ting Liu, Zhewei Shuai, Yifan Song, Qianzi Yang, Ying Wang, Hongjun Huang, Yan Luo
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2025-02-01
Serie:	Journal of Neuroinflammation
Ämnen:	Sepsis Sepsis-associated encephalopathy GDF15 Neuroinflammation Microglial phagocytosis
Länkar:	https://doi.org/10.1186/s12974-025-03369-8
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