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Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis

Abstract Background Sepsis-associated encephalopathy (SAE) is a severe neurological condition caused by sepsis, and presents with symptoms ranging from delirium and coma to long-term cognitive dysfunction. SAE is acknowledged as a widespread brain impairment characterized by the activation of microg...

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Uloženo v:
Hlavní autoři: Lijiao Chen, Shiyuan Luo, Ting Liu, Zhewei Shuai, Yifan Song, Qianzi Yang, Ying Wang, Hongjun Huang, Yan Luo
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2025-02-01
Edice:Journal of Neuroinflammation
Témata:
Sepsis
Sepsis-associated encephalopathy
GDF15
Neuroinflammation
Microglial phagocytosis
On-line přístup:https://doi.org/10.1186/s12974-025-03369-8
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