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The status of p53 affects the efficacy of PLK1 inhibitor BI6727 in prostate cancer cells

As there are no effective treatments for advanced prostate cancer, exploring new therapies is crucial. BI6727(Volasertib), a PLK1 inhibitor, shows great promise as an anti-cancer drug. However, despite advancing to phase II and III trials in other cancers, BI6727 has shown limited anti-tumor activit...

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Principais autores: Wenjing Li, Ying Wang, Wenzheng Guo, Donghua Wen
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2025-07-01
סדרה:Frontiers in Cell and Developmental Biology
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גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fcell.2025.1602693/full
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