The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration

Abstract Intervertebral disc degeneration (IVDD) is the primary contributor to a range of spinal diseases. Dynamin-related protein 1 (Drp1)-mediated mitochondrial fission has recently been identified as a new cause of nucleus pulposus cell (NPC) death and IVDD, but the underlying mechanisms remain u...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Zhidi Lin, Xiao Lu, Guangyu Xu, Jian Song, Hongli Wang, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Wei Zhu, Zuochong Yu, Xiaosheng Ma, Fei Zou
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2025-08-01
Serie:	Bone Research
Accesso online:	https://doi.org/10.1038/s41413-025-00449-6
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!