Bulk and single-cell transcriptome analysis reveal shared key genes and patterns of immune dysregulation in systemic lupus erythematosus and sepsis

Abstract Systemic lupus erythematosus (SLE) patients often experience sepsis, a significant clinical challenge that frequently requires intensive care and contributes significantly to morbidity and mortality. However, the molecular mechanisms underlying this comorbidity remain poorly understood. Thi...

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主要な著者:	Xuehuan Wen, Songjie Bai, Kangwei Sun, Kai Zhang, Ruomeng Hu, Shumin Li, Jie Yang, Lanxin Cao, Zhijian Cai, Gensheng Zhang
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2025-12-01
シリーズ:	Molecular Medicine
主題:	Sepsis Systemic lupus erythematosus PLSCR1 Single-cell transcriptome CD14+ monocyte
オンライン･アクセス:	https://doi.org/10.1186/s10020-025-01350-y
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