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Identification of shared neoantigens derived from frameshift mutations in the APC gene

Recent advances of cancer immunotherapy have identified neoantigens as essential targets for personalized treatments. However, since neoantigens are generally unique in individual cancers, neoantigen therapies that are more broadly applicable are eagerly awaited. Shared neoantigens, derived from rec...

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Principais autores: Peng Zhao, Clara Effenberger, Saki Matsumoto, Toshihiro Tanaka, Yusuke Nakamura, Kazuma Kiyotani
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-05-01
Serier:Frontiers in Immunology
Fag:
cancer immunotherapy
frameshift indels
frameshift neoantigen
shared neoantigens
T cell receptor
TCR-engineered T cells
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1574955/full
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