Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 DiCo in Complex with Its Natural Ligand PfRon2 Does Not Improve the In Vitro Efficacy

The blood-stage malaria vaccine candidate Plasmodium falciparum apical membrane antigen 1 (PfAMA1) can induce strong parasite growth-inhibitory antibody responses in animals but has not achieved the anticipated efficacy in clinical trials. Possible explanations in humans are the insufficient potency...

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Hlavní autoři:	Holger Spiegel, Alexander Boes, Rolf Fendel, Andreas Reimann, Stefan Schillberg, Rainer Fischer
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2017-06-01
Edice:	Frontiers in Immunology
Témata:	agroinfiltration growth inhibition assay plant molecular farming Plasmodium falciparum strain-transcending immune responses surface plasmon resonance spectroscopy
On-line přístup:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00743/full
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