The N-Terminal Region of the Transcription Factor E2F1 Contains a Novel Transactivation Domain and Recruits General Transcription Factor GTF2H2

The transcription factor E2F1 is the principal target of the tumor suppressor pRB. E2F1 promotes cell proliferation by activating growth-promoting genes upon growth stimulation. In contrast, E2F1 contributes to tumor suppression by activating tumor suppressor genes, such as <i>ARF</i>, upon loss of...

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Autors principals:	Lin Zhao, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Mariana Fikriyanti, Yuki Kamiya, Hiroyuki Toh, Hideyuki Komori, Ritsuko Iwanaga, Andrew P. Bradford, Hideo Nishitani, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-10-01
Col·lecció:	Biomolecules
Matèries:	E2F1 pRB ARF p53 transactivation domain GTF2H2
Accés en línia:	https://www.mdpi.com/2218-273X/14/11/1357
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