Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice.

This study aimed to determine whether the multi-kinase inhibitor dasatinib would provide an effective therapy for myeloproliferative diseases (MPDs) involving c-Cbl mutations. These mutations, which occur in the RING finger and linker domains, abolish the ability of c-Cbl to function as an E3 ubiqui...

Cijeli opis

Bibliografski detalji

Glavni autori:	Johanna M Duyvestyn, Samuel J Taylor, Samantha A Dagger, Marlene Orandle, Herbert C Morse, Christine B F Thien, Wallace Y Langdon
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2014-01-01
Serija:	PLoS ONE
Online pristup:	http://europepmc.org/articles/PMC3981816?pdf=render
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!