Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice.

This study aimed to determine whether the multi-kinase inhibitor dasatinib would provide an effective therapy for myeloproliferative diseases (MPDs) involving c-Cbl mutations. These mutations, which occur in the RING finger and linker domains, abolish the ability of c-Cbl to function as an E3 ubiqui...

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Bibliografiske detaljer

Principais autores:	Johanna M Duyvestyn, Samuel J Taylor, Samantha A Dagger, Marlene Orandle, Herbert C Morse, Christine B F Thien, Wallace Y Langdon
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2014-01-01
Serier:	PLoS ONE
Online adgang:	http://europepmc.org/articles/PMC3981816?pdf=render
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