Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains resistant to immunotherapy due to its immunosuppressive tumor microenvironment (TME) and impaired metabolic fitness of effector T cells. Here, we show that targeting UCP2 reprograms T‐cell metabolism, and that dual blockade with IL‐17 further...

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Detalhes bibliográficos

Principais autores:	Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-03-01
Colecção:	Advanced Science
Assuntos:	cytotoxic T cell immunotherapy interleukin‐17 pancreatic cancer uncoupling protein 2
Acesso em linha:	https://doi.org/10.1002/advs.202513020
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