Human TBK1 deficiency: An expanded spectrum from autoinflammation to viral encephalitisAutoinflammation and viral susceptibility in human TBK1 deficiency

Akalu et al. report new and long-term follow-up cases of human TBK1 deficiency, revealing that, beyond systemic autoinflammation, affected individuals are also vulnerable to severe viral encephalitis. Their findings highlight the dual nature of TBK1 deficiency—combining autoinflammatory disease with...

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Hauptverfasser:	Yemsratch Akalu, Justin Taft, Thomas Berger, Kevin Rostásy, Hormos S. Dafsari, Helena Schönrade, Müşerref Kasap Cüceoğlu, Seza Özen, Albert Faye, Isabelle Melki, Imen Dobroz, Odile Boespflug-Tanguy, Ayça Kiykim, Sezgin Sahin, Eda Tahir Turanli, Ümmüşen Kaya Akca, Jan A.M. van Laar, Philomine A. van Pelt, Iris H.I.M. Hollink, Pallavi Pimpale Chavan, Raju Khubchandani, Ivona Aksentijevich, Dusan Bogunovic
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Rockefeller University Press 2026-02-01
Schriftenreihe:	Journal of Human Immunity
Online-Zugang:	https://rupress.org/jhi/article-pdf/doi/10.70962/jhi.20250245/2026824/jhi_20250245.pdf
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