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Aldh1l1‐Cre/ERT2 Drives Flox‐Mediated Recombination in Peripheral and CNS Infiltrating Immune Cells in Addition to Astrocytes During CNS Autoimmune Disease

ABSTRACT Introduction The transgenic murine Cre/loxP system is deployed to investigate the role of central nervous system (CNS) cell‐specific gene alterations in both healthy conditions and models of neurologic disease. The Aldh1l1‐Cre/ERT2 line is widely used to target astrocytes with high coverage...

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Principais autores: Mario Amatruda, Juan Turati, Josh Weiss, Jorge Villavicencio, Zhihong Chen, Graham Britton, Sam Horng
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-02-01
Serier:Brain and Behavior
Fag:
Aldh1l1‐Cre
astrocyte‐specific promoter
central nervous system (CNS) autoimmune disease
CNS infiltrating immune cell
experimental autoimmune encephalomyelitis (EAE)
flow cytometry
Online adgang:https://doi.org/10.1002/brb3.70239
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