Aldh1l1‐Cre/ERT2 Drives Flox‐Mediated Recombination in Peripheral and CNS Infiltrating Immune Cells in Addition to Astrocytes During CNS Autoimmune Disease

ABSTRACT Introduction The transgenic murine Cre/loxP system is deployed to investigate the role of central nervous system (CNS) cell‐specific gene alterations in both healthy conditions and models of neurologic disease. The Aldh1l1‐Cre/ERT2 line is widely used to target astrocytes with high coverage...

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Hlavní autoři:	Mario Amatruda, Juan Turati, Josh Weiss, Jorge Villavicencio, Zhihong Chen, Graham Britton, Sam Horng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2025-02-01
Edice:	Brain and Behavior
Témata:	Aldh1l1‐Cre astrocyte‐specific promoter central nervous system (CNS) autoimmune disease CNS infiltrating immune cell experimental autoimmune encephalomyelitis (EAE) flow cytometry
On-line přístup:	https://doi.org/10.1002/brb3.70239
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