Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons

Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. However, the mislocalization and cytoplasmic aggregation of SFPQ are associated with the pathophysiology of...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Jocelyn Widagdo, Saumya Udagedara, Nishita Bhembre, Jing Zhi Anson Tan, Lara Neureiter, Jie Huang, Victor Anggono, Mihwa Lee
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	The Royal Society 2022-09-01
Σειρά:	Open Biology
Θέματα:	amyotrophic lateral sclerosis protein aggregation DBHS proteins glutamate receptors RNA binding proteins zinc
Διαθέσιμο Online:	https://royalsocietypublishing.org/doi/10.1098/rsob.220187
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