Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease
People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene. Inheriting two copies of these APOL1 risk variants, known as G1 and G2, causes high rates of focal...
Bewaard in:
| Hoofdauteurs: | , , , , , , , , , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Company of Biologists
2021-08-01
|
| Reeks: | Disease Models & Mechanisms |
| Onderwerpen: | |
| Online toegang: | http://dmm.biologists.org/content/14/8/dmm048952 |
| Tags: |
Geen labels, Wees de eerste die dit record labelt!
|