Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease

People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene. Inheriting two copies of these APOL1 risk variants, known as G1 and G2, causes high rates of focal...

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Bibliografiske detaljer

Principais autores:	Gizelle M. McCarthy, Angelo Blasio, Olivia G. Donovan, Lena B. Schaller, Althea Bock-Hughes, Jose M. Magraner, Jung Hee Suh, Calum F. Tattersfield, Isaac E. Stillman, Shrijal S. Shah, Zsuzsanna K. Zsengeller, Balajikarthick Subramanian, David J. Friedman, Martin R. Pollak
Format:	Artigo
Sprog:	Inglês
Udgivet:	The Company of Biologists 2021-08-01
Serier:	Disease Models & Mechanisms
Fag:	apol1 kidney mouse transgenic
Online adgang:	http://dmm.biologists.org/content/14/8/dmm048952
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