Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation

Objective. Pigment epithelium-derived factor (PEDF) plays an important role in obesity-induced insulin resistance (IR). The study aims to investigate the effect of metformin, a widely used agent to improve IR, on PEDF production both in vivo and in vitro. Methods. SD rats were divided into normal co...

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Detalhes bibliográficos

Principais autores:	Shumin Yang, Qiong Lv, Ting Luo, Lulu Liu, Rufei Gao, Shumei Chen, Peng Ye, Qingfeng Cheng, Qifu Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2013-01-01
Colecção:	Mediators of Inflammation
Acesso em linha:	http://dx.doi.org/10.1155/2013/429207
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