Construction of stable packaging cell lines for large-scale industrial BaEV-enveloped retroviral vector production

IntroductionViral vectors with Baboon endogenous virus (BaEV) envelope proteins have been demonstrated to markedly increase gene transfer efficiency to NK cells. Nevertheless, the cytotoxicity of the BaEV envelope protein necessitates the production of this type of viral vector by transient transfec...

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Autori principali:	Lijun Zhao, Chunting Qiu, Hanyi Chen, Zhuoying Yu, Jiaqi Fan, Qihong Ma, Sijian Zhan, Yaru Feng, Xiaorui Li, Ping Ma, Weijia Wang, Yuanyuan Shi, Jin-fu Xu, Jianxun Wang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-05-01
Serie:	Frontiers in Immunology
Soggetti:	BaEV-enveloped retrovirus stable packaging cell line industrial-large-scale production CAR-NK cell therapy ASCT-1/2 knockout
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578660/full
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