Construction of stable packaging cell lines for large-scale industrial BaEV-enveloped retroviral vector production

IntroductionViral vectors with Baboon endogenous virus (BaEV) envelope proteins have been demonstrated to markedly increase gene transfer efficiency to NK cells. Nevertheless, the cytotoxicity of the BaEV envelope protein necessitates the production of this type of viral vector by transient transfec...

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Hlavní autoři:	Lijun Zhao, Chunting Qiu, Hanyi Chen, Zhuoying Yu, Jiaqi Fan, Qihong Ma, Sijian Zhan, Yaru Feng, Xiaorui Li, Ping Ma, Weijia Wang, Yuanyuan Shi, Jin-fu Xu, Jianxun Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-05-01
Edice:	Frontiers in Immunology
Témata:	BaEV-enveloped retrovirus stable packaging cell line industrial-large-scale production CAR-NK cell therapy ASCT-1/2 knockout
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578660/full
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