Quinoline carboxylic acid derivatives as potent ectonucleotidase inhibitors

Abstract Ectonucleotidases, including h-NTPDases, h-ENPP, and h-e5′NT, play a crucial role in regulating extracellular nucleotide levels by converting ATP into immunosuppressive adenosine, thereby facilitating tumor immune evasion. Inhibiting these enzymes can restore antitumor immunity by preventin...

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Bibliografiske detaljer

Principais autores:	Aqsa Ishaq, Ismat Nawaz, Javeria Qadir, Salman Alrokayan, Tajamul Hussain, Nicolly Espindola Gelsleichter, Julie Pelletier, Jean Sévigny, Muhammad Muhammad, Qing Huang, Jamshed Iqbal
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-02-01
Serier:	Scientific Reports
Fag:	Ectonucleotidases Quinoline derivatives Enzyme inhibition Molecular docking DFT studies Fluorescence analysis
Online adgang:	https://doi.org/10.1038/s41598-026-36994-1
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