Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) – a promising target for the immunotherapy of cancer

IntroductionHeparins, naturally occurring glycosaminoglycans, are widely used for thrombosis prevention. Upon application as anticoagulants in cancer patients, heparins were found to possess additional antitumor activities. Ectonucleotidases have recently been proposed as novel targets for cancer im...

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Autors principals:	Vittoria Lopez, H. J. Maximilian Schuh, Salahuddin Mirza, Victoria J. Vaaßen, Michael S. Schmidt, Katharina Sylvester, Riham M. Idris, Christian Renn, Laura Schäkel, Julie Pelletier, Jean Sévigny, Annamaria Naggi, Björn Scheffler, Sang-Yong Lee, Gerd Bendas, Christa E. Müller
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-08-01
Col·lecció:	Frontiers in Immunology
Matèries:	adenosine ectonucleotidase inhibitors immuno-oncology NPP1 U87 glioblastoma cells heparin
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1173634/full
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