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BRAF/MEK inhibitors use for pediatric gliomas; real world experience from a resource-limited country

IntroductionMost pediatric low-grade-gliomas (LGG) and some high-grade-gliomas (HGG) have alterations in the RAS/MAPK pathway. Promising high tumor response rates were achieved using BRAF/MEK inhibitors, however data on their use in low-middle-income-countries (LMICs) are limited.MethodsWe retrospec...

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Principais autores: Dima Abu Laban, Abeer Alsharif, Maysa Al-Hussaini, Mouness Obeidat, Bayan Maraqa, Qasem Alzoubi, Awni Musharbash, Saad Jaddoua, Raed Ramlawi, Kawther Khaleifeh, Ahmad Kh. Ibrahimi, Nasim Sarhan, Eric Bouffet, Nisreen Amayiri
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-09-01
Serier:Frontiers in Oncology
Fag:
BRAF/MEK inhibitors
dabrafenib
trametinib
low-middle-income countries (LMIC)
targeted therapy
glioma
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2024.1417484/full
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