Adjacent Cell Marker Lateral Spillover Compensation and Reinforcement for Multiplexed Images

Multiplex imaging technologies are now routinely capable of measuring more than 40 antibody-labeled parameters in single cells. However, lateral spillage of signals in densely packed tissues presents an obstacle to the assignment of high-dimensional spatial features to individual cells for accurate...

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Autors principals:	Yunhao Bai, Bokai Zhu, Xavier Rovira-Clave, Han Chen, Maxim Markovic, Chi Ngai Chan, Tung-Hung Su, David R. McIlwain, Jacob D. Estes, Leeat Keren, Garry P. Nolan, Sizun Jiang
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-07-01
Col·lecció:	Frontiers in Immunology
Matèries:	multiplexed tissue imaging spatial proteomics signal spillover image correction single-cell biology cell annotation
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.652631/full
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