Adjacent Cell Marker Lateral Spillover Compensation and Reinforcement for Multiplexed Images

Multiplex imaging technologies are now routinely capable of measuring more than 40 antibody-labeled parameters in single cells. However, lateral spillage of signals in densely packed tissues presents an obstacle to the assignment of high-dimensional spatial features to individual cells for accurate...

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Detalhes bibliográficos

Principais autores:	Yunhao Bai, Bokai Zhu, Xavier Rovira-Clave, Han Chen, Maxim Markovic, Chi Ngai Chan, Tung-Hung Su, David R. McIlwain, Jacob D. Estes, Leeat Keren, Garry P. Nolan, Sizun Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-07-01
coleção:	Frontiers in Immunology
Assuntos:	multiplexed tissue imaging spatial proteomics signal spillover image correction single-cell biology cell annotation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.652631/full
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