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Selective sodium iodide symporter (NIS) gene therapy of glioblastoma mediated by EGFR-targeted lipopolyplexes

Lipo-oligomers, post-functionalized with ligands to enhance targeting, represent promising new vehicles for the tumor-specific delivery of therapeutic genes such as the sodium iodide symporter (NIS). Due to its iodide trapping activity, NIS is a powerful theranostic tool for diagnostic imaging and t...

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Principais autores: Rebekka Spellerberg, Teoman Benli-Hoppe, Carolin Kitzberger, Simone Berger, Kathrin A. Schmohl, Nathalie Schwenk, Hsi-Yu Yen, Christian Zach, Franz Schilling, Wolfgang A. Weber, Roland E. Kälin, Rainer Glass, Peter J. Nelson, Ernst Wagner, Christine Spitzweg
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-12-01
Serier:Molecular Therapy: Oncolytics
Fag:
sodium iodide symporter
NIS
glioblastoma
GBM
gene therapy
polyplexes
Online adgang:http://www.sciencedirect.com/science/article/pii/S2372770521001480
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