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The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy

Abstract Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in non-thyroidal tumors followed by application of therapeutic radionuclides. This...

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Hlavní autoři: Carolin Kitzberger, Rebekka Spellerberg, Volker Morath, Nathalie Schwenk, Kathrin A. Schmohl, Christina Schug, Sarah Urnauer, Mariella Tutter, Matthias Eiber, Franz Schilling, Wolfgang A. Weber, Sibylle Ziegler, Peter Bartenstein, Ernst Wagner, Peter J. Nelson, Christine Spitzweg
Médium: Artigo
Jazyk:Inglês
Vydáno: SpringerOpen 2022-05-01
Edice:EJNMMI Research
Témata:
Sodium iodide symporter
[18F]tetrafluoroborate
124I
PET
Glioblastoma
Gene therapy
On-line přístup:https://doi.org/10.1186/s13550-022-00888-w
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