Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4

Summary: Changes to cellular lipids accompany shifts in microglial cell state, but the functional significance of these metabolic changes remains poorly understood. In human induced pluripotent stem cell-derived microglia, we observed that both extrinsic activation (by lipopolysaccharide treatment)...

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Principais autores:	Roxan A. Stephenson, Jordy Sepulveda, Kory R. Johnson, Adrian Lita, Jaanam Gopalakrishnan, Dominic J. Acri, Alexandra Beilina, Linling Cheng, Linda G. Yang, Jessica T. Root, Michael E. Ward, Christian Combs, William C. Skarnes, Mark R. Cookson, Han-Yu Shih, Mioara Larion, G. William Rebeck, Priyanka S. Narayan
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-07-01
Series:	Cell Reports
Assuntos:	CP: Neuroscience
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124725007326
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