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Small animal PET imaging with the 68Ga-labeled pH (low) insertion peptide-like peptide YJL-4 in a triple-negative breast cancer mouse model

Abstract Background The aim of this study was to prepare a novel 68Ga-labeled pH (low) insertion peptide (pHLIP)-like peptide, YJL-4, and determine its value for the early diagnosis of triple-negative breast cancer (TNBC) via in vivo imaging of tumor-bearing nude mice. The novel peptide YJL-4 was de...

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Principais autores: YueHua Chen, ShuangShuang Song, YanQin Sun, FengYu Wu, GuangJie Yang, ZhenGuang Wang, MingMing Yu
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2024-04-01
coleção:EJNMMI Radiopharmacy and Chemistry
Assuntos:
Triple-negative breast cancer
Tumor microenvironment
pH (low) insertion peptides
68Ga
Small animal PET/CT
Molecular imaging
Acesso em linha:https://doi.org/10.1186/s41181-024-00267-x
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