Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis

Deuterated water (2H2O) is widely used for measuring de novo lipogenesis (DNL). 2H is incorporated into fatty acids via exchange between body water and the hydrogens of acetyl-CoA, malonyl-CoA, and NADPH. Previous studies concluded that these exchanges are incomplete; therefore, fatty acid 2H enrich...

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Bibliografiske detaljer

Principais autores:	Getachew Debas Belew, Joao Silva, Joao Rito, Ludgero Tavares, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, Maria Paula Macedo, John G. Jones
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2019-12-01
Serier:	Journal of Lipid Research
Fag:	pentose phosphate pathway deuterium nuclear magnetic resonance acetyl-coenzyme A malonyl-coenzyme A reduced nicotinamide adenine dinucleotide phosphate
Online adgang:	http://www.sciencedirect.com/science/article/pii/S0022227520310439
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