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Prevalence of katG and inhA mutations associated with isoniazid resistance in Mycobacterium tuberculosis clinical isolates in Cameroon

Abstract Background The acquisition of isoniazid (INH) resistance is alarming, considering its importance as a key drug that forms the core of multidrug treatment regimens for tuberculosis (TB). Genetic mutations in the katG and inhA promoter regions play crucial roles in INH resistance, but their p...

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Principais autores: Vanessa Ninkeh Nono, Edouard Akono Nantia, Awelani Mutshembele, Sorelle Nguimfack Teagho, Yannick Willy Kamdem Simo, Brenda Shile Takong, Yvonne Josiane Djieugoue, Yannick Patrick Assolo, Suzanne Magloire Ongboulal, Stanley Nkemnji Awungafac, Sara Eyangoh, Eric Mensah, Ndivhuho Agnes Makhado, Valerie Flore Donkeng Donfack
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-03-01
coleção:BMC Microbiology
Assuntos:
Mycobacterium tuberculosis
Isoniazid resistance
katG
inhA
Mutations
Cameroon
Acesso em linha:https://doi.org/10.1186/s12866-025-03816-9
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