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Prevalence of katG and inhA mutations associated with isoniazid resistance in Mycobacterium tuberculosis clinical isolates in Cameroon

Abstract Background The acquisition of isoniazid (INH) resistance is alarming, considering its importance as a key drug that forms the core of multidrug treatment regimens for tuberculosis (TB). Genetic mutations in the katG and inhA promoter regions play crucial roles in INH resistance, but their p...

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Autori principali: Vanessa Ninkeh Nono, Edouard Akono Nantia, Awelani Mutshembele, Sorelle Nguimfack Teagho, Yannick Willy Kamdem Simo, Brenda Shile Takong, Yvonne Josiane Djieugoue, Yannick Patrick Assolo, Suzanne Magloire Ongboulal, Stanley Nkemnji Awungafac, Sara Eyangoh, Eric Mensah, Ndivhuho Agnes Makhado, Valerie Flore Donkeng Donfack
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-03-01
Serie:BMC Microbiology
Soggetti:
Mycobacterium tuberculosis
Isoniazid resistance
katG
inhA
Mutations
Cameroon
Accesso online:https://doi.org/10.1186/s12866-025-03816-9
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