Preliminary SAR of Novel Pleuromutilin–Polyamine Conjugates

While pleuromutilin (<b>1</b>) and its clinically available derivatives (<b>2</b>–<b>6</b>) are highly effective against Gram-positive bacteria, they remain inactive against many pathogenic Gram-negative bacteria due to the efflux pump AcrAB-TolC. In an effort to broaden the spectrum of activity of...

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Principais autores:	Kenneth Sue, Melissa M. Cadelis, Kerrin Hainsworth, Florent Rouvier, Marie-Lise Bourguet-Kondracki, Jean Michel Brunel, Brent R. Copp
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2023-11-01
叢編:	Microorganisms
主題:	polyamine pleuromutilin antimicrobial antibiotic enhancement membrane disruption
在線閱讀:	https://www.mdpi.com/2076-2607/11/11/2791
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