Prions amplify through degradation of the VPS10P sorting receptor sortilin.
Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein, PrPSc. A pivotal pathogenic event in prion disease is progressive accumulation of prions, or PrPSc, in brains through constitutive conformational...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2017-06-01
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| coleção: | PLoS Pathogens |
| Acesso em linha: | https://doi.org/10.1371/journal.ppat.1006470 |
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