Persistent CD8+ T cell-driven immune dysregulation despite normalized CD4+ T cell recovery in ART-treated people living with HIV

BackgroundDespite successful antiretroviral therapy (ART) that restores CD4+ T cell counts and reduces HIV viral loads to undetectable levels, a substantial proportion of people living with HIV (PLWH) exhibit persistent CD4/CD8 ratio inversion. This abnormal ratio is primarily driven by sustained CD...

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主要な著者:	Yiyao Hu, Lingyun Ge, Yun He, Xiaorui Li, Yinsong Luo, Hui Wu, Jiayi He, Chao Zhang, Jiaye Liu
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2026-02-01
シリーズ:	Frontiers in Immunology
主題:	antiretroviral therapy CD4/CD8 ratio CD8+ T cells HIV immune dysregulation
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1735779/full
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