Persistent CD8+ T cell-driven immune dysregulation despite normalized CD4+ T cell recovery in ART-treated people living with HIV

BackgroundDespite successful antiretroviral therapy (ART) that restores CD4+ T cell counts and reduces HIV viral loads to undetectable levels, a substantial proportion of people living with HIV (PLWH) exhibit persistent CD4/CD8 ratio inversion. This abnormal ratio is primarily driven by sustained CD...

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Principais autores:	Yiyao Hu, Lingyun Ge, Yun He, Xiaorui Li, Yinsong Luo, Hui Wu, Jiayi He, Chao Zhang, Jiaye Liu
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-02-01
Serija:	Frontiers in Immunology
Teme:	antiretroviral therapy CD4/CD8 ratio CD8+ T cells HIV immune dysregulation
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1735779/full
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