Molecular and clinicopathologic features of gliomas harboring NTRK fusions

Abstract Fusions involving neurotrophic tyrosine receptor kinase (NTRK) genes are detected in ≤2% of gliomas and can promote gliomagenesis. The remarkable therapeutic efficacy of TRK inhibitors, which are among the first Food and Drug Administration-approved targeted therapies for NTRK-fused gliomas...

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Bibliografske podrobnosti

Principais autores:	Matthew Torre, Varshini Vasudevaraja, Jonathan Serrano, Michael DeLorenzo, Seth Malinowski, Anne-Florence Blandin, Melanie Pages, Azra H. Ligon, Fei Dong, David M. Meredith, MacLean P. Nasrallah, Craig Horbinski, Sonika Dahiya, Keith L. Ligon, Mariarita Santi, Shakti H. Ramkissoon, Mariella G. Filbin, Matija Snuderl, Sanda Alexandrescu
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2020-07-01
Serija:	Acta Neuropathologica Communications
Teme:	NTRK Glioma NGS sequencing Methylation
Online dostop:	http://link.springer.com/article/10.1186/s40478-020-00980-z
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