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Genetic interference with HvNotch provides new insights into the role of the Notch-signalling pathway for developmental pattern formation in Hydra

Abstract The Notch-signalling pathway plays an important role in pattern formation in Hydra. Using pharmacological Notch inhibitors (DAPT and SAHM1), it has been demonstrated that HvNotch is required for head regeneration and tentacle patterning in Hydra. HvNotch is also involved in establishing the...

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Bibliografiske detaljer
Principais autores: Qin Pan, Moritz Mercker, Alexander Klimovich, Jörg Wittlieb, Anna Marciniak-Czochra, Angelika Böttger
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-04-01
Serier:Scientific Reports
Online adgang:https://doi.org/10.1038/s41598-024-58837-7
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