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N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins

The mRNA 5′ cap consists of N7-methylguanosine bound by a 5′,5′-triphosphate bridge to the first nucleotide of the transcript. The cap interacts with various specific proteins and participates in all key mRNA-related processes, which may be of therapeutic relevance. There is a grow...

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Autori principali: Michal Kopcial, Blazej A. Wojtczak, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2019-05-01
Serie:Molecules
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Accesso online:https://www.mdpi.com/1420-3049/24/10/1899
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