Motif models proposing independent and interdependent impacts of nucleotides are related to high and low affinity transcription factor binding sites in Arabidopsis

Position weight matrix (PWM) is the traditional motif model representing the transcription factor (TF) binding sites. It proposes that the positions contribute independently to TFs binding affinity, although this hypothesis does not fit the data perfectly. This explains why PWM hits are missing in a...

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Главные авторы:	Anton V. Tsukanov, Victoria V. Mironova, Victor G. Levitsky
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2022-07-01
Серии:	Frontiers in Plant Science
Предметы:	de novo motif search heterogeneity of transcription factor binding sites high and low affinity of transcription factor binding sites standard and alternative motif recognition models ChIP-seq data analysis
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fpls.2022.938545/full
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